Biomedical Engineering (BME) is the application of engineering principles and design concepts to medicine and biology for healthcare purposes (e.g. diagnostic or therapeutic). This field seeks to close the gap between engineering and medicine: It combines the design and problem solving skills of engineering with medical and biological sciences to advance health care treatment, including diagnosis, monitoring, and therapy. Biomedical sciences, are a set of applied sciences applying portions of natural science or formal science, or both, to develop knowledge, interventions, or technology of use in healthcare or public health Such disciplines as medical microbiology, clinical virology, clinical epidemiology, genetic epidemiology, and biomedical engineering are medical sciences. Explaining physiological mechanisms operating in pathological processes, however, pathophysiology can be regarded as basic science. Biomedical technology broadly refers to the application of engineering and technology principles to the domain of living or biological systems. Usually inclusion of the term biomedical denotes a principal emphasis on problems related to human health and diseases, whereas terms like "biotechnology" can be medical, environmental, or agricultural in application. But most terms in this general realm still lack clear boundaries. Biomedical engineering and Biotechnology alike are often loosely called Biomedical Technology or Bioengineering.